They're just scared and the needle phobia doesn't help either, but there will be topical version soon. I'm sure those people claiming that constantly eat and drink carcinogenic stuff.
"Evidence for alpha-melanocyte-stimulating hormone (alpha-MSH) receptors on human malignant melanoma cells.
The presence of alpha-MSH receptors on human melanoma has so far been suggested in the literature but not proved. We describe a reproducible and specific binding assay of alpha-MSH on human melanoma cells, using a high-specific-activity 125I-labelled hormone (1.5 to 2 mCi/micrograms) with consistent receptor binding (usually exceeding 2 pg/10(6) cells) and stable for 3 weeks. Asynchronized cells in suspension were incubated for 15 min at 37 degrees C with the tracer and various concentrations of unlabelled hormones. Synthetic alpha-MSH was compared to beta-MSH, ACTH1-24, ACTH4-10, beta-LPH, CLIP, CRF, MIF I, A8VP and beta-endorphin. Out of a panel of 8 human melanoma cell lines, 3 showed specific and reproducible alpha-MSH binding curves. No significant binding to human fibroblast and human carcinoma cells was seen. alpha-MSH, beta-MSH and, to a lesser extent ACTH4-10 (a part of the alpha-MSH sequence) were the only peptides able to displace labelled alpha-MSH from its binding sites, indicating the high specificity of the MSH receptor. Affinity constants (Ka) ranged from 10(8) to 10(9) l/mole and the estimated receptor number was 1,000 to 2,000 per cell. We conclude that some human melanoma cell lines expressed specific MSH receptors with stable affinity but which are low in number."
MT2 doesn't appear to be a direct carcinogen but if melanoma cells really do express alpha-MSH receptors then one has to wonder if MT2 will stimulate existing skin cancers. Combined with the Catch 22 that is MT2 is supposed to protect against skin cancer, however MT2 users are more apt to stay in the sun longer and burn, I suggest MT2 seems to be strictly for cosmetic use in it's current state.
Proper MT usage darkens skin with just 16mg and without skin usage. Perhaps this method will protect against skin cancer, users are trying to replicate this using insulin pump configurations...
Many people on local forums in my country, also claims that over-stimulation of melanocytes causing cancer in those cells, but it is clear that those who say this have never used MT or studied it.
I have not even reached the color of 16mg. For me it took over 2 months and almost 40mg.
"
MT2 doesn't appear to be a direct carcinogen but if melanoma cells really do express alpha-MSH receptors then one has to wonder if MT2 will stimulate existing skin cancers. Combined with the Catch 22 that is MT2 is supposed to protect against skin cancer, however MT2 users are more apt to stay in the sun longer and burn, I suggest MT2 seems to be strictly for cosmetic use in it's current state.
Proper MT usage darkens skin with just 16mg and without skin usage. Perhaps this method will protect against skin cancer, users are trying to replicate this using insulin pump configurations...
"
Thank you bdvince, are you able to elaborate on the curiosity about MT2 usage stimulating existing cancers?
Is your assumption the melanotan peptide users are irresponsible/improper when tanning the skin (overall and/or while having/developing skin cancer)?
My observations conclude overwhelmingly that MT2 offers protection (particularly given my fair skin type).
"Evidence for alpha-melanocyte-stimulating hormone (alpha-MSH) receptors on human malignant melanoma cells.
The presence of alpha-MSH receptors on human melanoma has so far been suggested in the literature but not proved. We describe a reproducible and specific binding assay of alpha-MSH on human melanoma cells, using a high-specific-activity 125I-labelled hormone (1.5 to 2 mCi/micrograms) with consistent receptor binding (usually exceeding 2 pg/10(6) cells) and stable for 3 weeks. Asynchronized cells in suspension were incubated for 15 min at 37 degrees C with the tracer and various concentrations of unlabelled hormones. Synthetic alpha-MSH was compared to beta-MSH, ACTH1-24, ACTH4-10, beta-LPH, CLIP, CRF, MIF I, A8VP and beta-endorphin. Out of a panel of 8 human melanoma cell lines, 3 showed specific and reproducible alpha-MSH binding curves. No significant binding to human fibroblast and human carcinoma cells was seen. alpha-MSH, beta-MSH and, to a lesser extent ACTH4-10 (a part of the alpha-MSH sequence) were the only peptides able to displace labelled alpha-MSH from its binding sites, indicating the high specificity of the MSH receptor. Affinity constants (Ka) ranged from 10(8) to 10(9) l/mole and the estimated receptor number was 1,000 to 2,000 per cell. We conclude that some human melanoma cell lines expressed specific MSH receptors with stable affinity but which are low in number."
MT2 doesn't appear to be a direct carcinogen but if melanoma cells really do express alpha-MSH receptors then one has to wonder if MT2 will stimulate existing skin cancers. Combined with the Catch 22 that is MT2 is supposed to protect against skin cancer, however MT2 users are more apt to stay in the sun longer and burn, I suggest MT2 seems to be strictly for cosmetic use in it's current state.
Proper MT usage darkens skin with just 16mg and without skin usage. Perhaps this method will protect against skin cancer, users are trying to replicate this using insulin pump configurations...
"
Hi Bdvince, well argued post.
In my opinion the protection exist, as the melanocytes act by itself as a protective agent.
As the Melanoma contains MSH-receptors it always shows activity when exposed to MSH, we have seen many cases of people who discover a preexisting melanoma after MSH usage, thanks to its pigmentary effect. BUT it doesnt mean that the msh boost the melanoma, it only means that the msh makes more visible pre existing melanoma. PUBmed is full of studies which can prove this. What is true is that it appears that sinthetic msh seems to low inmune system for short time frames.
but once your body is used to the peptide, the low immune system reaction should be gone? And does it get helped with healthy lifestyle,....like it's just a small part of many things people do to boost or not to boost their immune system.
all I can say if you already have melanoma then what in the hell are you trying to tan or even exposing your self to sun* , the cancer removed before it spreads it also might be nodular* melanoma it is the most aggressive type of skin cancer.
Well,
I wont tell you to tan in you suffer melanoma, but it has also been tested that sun exposure produces Vitamin D, and in many Melanoma cases has also been shown a Vitamin D deficit.
I dont want to say that sun prevents Melanoma but i dont really believe that sun is the main problem cause of* melanoma but the bad sun exposure habbits.
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