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  1. #21 4th August 2014 
    Djen's Avatar
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    Re: Topical Alternatives

    we have to wait and see, a few members over here are starting a forskolin trial.
    I see some first results with melitane after a good seven weeks. This week I'll know if the PH levels of the water I've used are good;

    Over here is a pulled eyebrow hair that has darkened next to a hair that hasn't darkened yet]
    http://imgur.com/ubwLVCJ
  2. #22 4th August 2014 
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    Re: Topical Alternatives

    Oh no, now that after a good seven weeks I seem to have noticed some first results, I can no longer find the product on ebay and I'm almost running out of melitane ( acetyl hexapeptide)
  3. #23 6th August 2014 
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    Re: Topical Alternatives

    "
    Oh no, now that after a good seven weeks I seem to have noticed some first results, I can no longer find the product on ebay and I'm almost running out of melitane ( acetyl hexapeptide)
    "


    Try contacting your supplier via their mail system, you'll find his username in the "Won" section. He may still be able to supply it off of eBay.


    Chances are eBay or the producer has forced them to remove it.




    And as a side note, had a few quotes back for Forskolin 98% - averaging around $150/20mg vial. One was considerably cheaper but there isn't much backing up their company like the others.


    Tom
  4. #24 6th August 2014 
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    Re: Topical Alternatives

    Hey Tom, how much of an actual forskolin product could you have with that batch? It might be worth it for eyelashes or brows but a maintaining a full body might be a bit expensive.

    I've contacted the supplier, he will be back in september, he's on holidays. But there are people over here having contacted me on acetyl hexapeptide. It's not expensive at all. I'm also looking for a better formula than the one I've used.
  5. #25 6th August 2014 
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    Re: Topical Alternatives

    "
    Hey Tom, how much of an actual forskolin product could you have with that batch? It might be worth it for eyelashes or brows but a maintaining a full body might be a bit expensive.

    I've contacted the supplier, he will be back in september, he's on holidays. But there are people over here having contacted me on acetyl hexapeptide. It's not expensive at all. I'm also looking for a better formula than the one I've used.
    "


    We're not too sure at the moment, to be honest with you. Have a couple of people looking into getting something made up but from what they suspect it wont be feasible until the price drops considerably.


    Hopefully he'll be back before you run out, or you can find another supplier then! Would be a shame to waste two months of building up to it, only to have to stop
    I've not really looked into it, is there much research behind it?

    Tom
  6. #26 6th August 2014 
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    Re: Topical Alternatives

    When you google acetyl hexapeptide 1 and melanin you can find a lot of hits.* The ebay seller told me: use 5 pct dimethyl isosorbide, 5 pct melitane and 90 pct water. I don't know if this is the best way to use, there are probably better ways but it seems to start doing something now.

    I won't have enough product left so I'll just apply it to a small piece of my hair and eyebrows, lashes.

    I've never heard the 98 pct forskolin is necessary to make it work. It would be a shame as scientific reports really seem to prove it works.
  7. #27 6th August 2014 
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    Re: Topical Alternatives

    "
    When you google acetyl hexapeptide 1 and melanin you can find a lot of hits.* The ebay seller told me]
    I've never heard the 98 pct forskolin is necessary to make it work. It would be a shame as scientific reports really seem to prove it works.
    "


    I'd imagine that's the most accessible/cost effective method. There are probably other components that could amplify or speed up the process but would be harder to get hold of?


    I've never actually seen what percentage they use, but there are a few mentions of 'pure'/etc. I may have skimmed over that but I'm not too sure?
    The only other issue is most plant extracts come in standard %, which are 10, 20, 30, 40, 98. It may be that 40 is too weak but 98 is overkill, in this case it may work out more expensive to purchase anything between 41-97% because it would be a custom order.


    The other issues are that the most promising report was conducted on rats, their skin is much easier to penetrate and the surface area of a rat is minuscule when compared to a human.
    They may well have been able to shell out for 98% due to the fact they would have needed far less.


    Tom
  8. #28 6th August 2014 
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    Re: Topical Alternatives

    Let's also watch out for JROD's results and remember it often takes longer than 1-2 weeks. Could a mix between a small percentage of the 98 pct and 20 pct forskolin be the solution? We could use a few real scientists on this board. Maybe there are some "active" forums where we could find them.
  9. #29 6th August 2014 
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    Re: Topical Alternatives

    "
    Let's also watch out for JROD's results and remember it often takes longer than 1-2 weeks. Could a mix between a small percentage of the 98 pct and 20 pct forskolin be the solution? We could use a few real scientists on this board. Maybe there are some "active" forums where we could find them.
    "


    Hopefully it all comes out well, there are many people who would benefit from a topical, especially the forum users.
    There is an odd (although logical) trend on the forums that I have noticed where most people are FP skin tone 1 or 2; and these are the people who would benefit from a hair darkening topical.


    Even though lots of type 3 and 4 (maybe even 5 and 6, so as not to discriminate) people use it they generally take a more 'I want a tan as fast as possible' approach; and thus don't research about it.


    -Gone off on a tangent a bit there -


    --EDIT 06/08/14 23]As to the 98% and 20%, it more than likely just waste the 20% if its not potent enough to start working? I'm not a scientist, though, so I'm just speculating.
    We have real scientists! Unfortunately, its not their line of expertise so they only have a slightly better footing than us. It may even be valuable input from anyone in the cosmetics industry, as I imagine these are issues faced before.

    Tom
  10. #30 6th August 2014 
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    Re: Topical Alternatives

    I've posted on chemist corner but as yet no replies. I think it would be more interesting to find out about more cosmetic formulators as you say, they're usually not as nerdy. :-)
  11. #31 7th August 2014 
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    Re: Topical Alternatives

    "
    I've posted on chemist corner but as yet no replies. I think it would be more interesting to find out about more cosmetic formulators as you say, they're usually not as nerdy. ]"


    Hopefully somebody gets in touch with some general knowledge of formulating it, we'll be trying out of a personal interest in the topic but it's not what our company is specialized in.


    And considering 1g of F98 is $7500, its going to be expensive if working on a trial and error basis.


    Tom
  12. #32 7th August 2014 
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    Re: Topical Alternatives

    This study sorta implies the lower versions should work: http://www.ncbi.nlm.nih.gov/pubmed/19281221
    I wonder if researchers would even start studying something that is that expensive so it kind of sounds logical.
  13. #33 12th August 2014 
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    Re: Topical Alternatives

    http://www.microformulation.com/?doing_wp_cron=1407868562.1174499988555908203125* * just an idea, might help us.
  14. #34 24th August 2014 
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    Re: Topical Alternatives

    http://www.google.com/patents/WO2014081845A2?cl=en

    So here's the patent application for the MC1R agonist, analog that should be topically applicable.

    If any people know a good chemist that information might be useful
  15. #35 24th August 2014 
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    Re: Topical Alternatives

    Reading through the application is actually really interesting, apparently by focussing on the MC1R it will be similar to MT2 minus all the fatigue and libido side effects. Also small enough to penetrate skin easily without difficult formulas. To the guy who is currently spending money on Forskolin trials, it might be worth having some of this made up instead.
  16. #36 24th August 2014 
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    Re: Topical Alternatives

    Thank you, Londonboy. The near future is looking bright. I'm starting to get results with melitane and this seems to be another big step forward.
  17. #37 1st September 2014 
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    Re: Topical Alternatives

    Can't believe no one has elaborated on this yet, sounds so promising and more practical.
  18. #38 1st September 2014 
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    Re: Topical Alternatives

    It certainly does. The crazy thing about it as well, is that you won't need UV exposure. It will stimulate the tanning response without having to actually expose yourself to UV therefore completely eliminating cancer concerns and the need for sun beds etc.

    Almost sounds too good to be true, but preliminary tests on culture human skin samples seem to be really promising. Only concern from me, is that Zalfa Abdel Malek and co have been working on this for 8+ years so it might be a while still before it's commercially available.
  19. #39 1st September 2014 
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    Re: Topical Alternatives

    Melanotan injectables are not commercially available yet either but people have been using them for a while now. There should be a way to make it work on people already, is also more practical when going on holidays.
  20. #40 1st September 2014 
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    Re: Topical Alternatives

    "
    It certainly does. The crazy thing about it as well, is that you won't need UV exposure. It will stimulate the tanning response without having to actually expose yourself to UV therefore completely eliminating cancer concerns and the need for sun beds etc.

    Almost sounds too good to be true, but preliminary tests on culture human skin samples seem to be really promising. Only concern from me, is that Zalfa Abdel Malek and co have been working on this for 8+ years so it might be a while still before it's commercially available.
    "

    She has said that she's hoping it will be in clinical trials within 2-3 years. http://healthnews.uc.edu/news/?/24818/