My apologies as well JROD, your .02 is legit and on par with the mainstream. Pardon my being short on the subj... I just know many who have spent a great deal of energy and money to ensure advertisers* serving communities are worth their salt. Further think there are updates within the industry and the Chinese concern is outdated. Most do however purchase blindly and it is a shame, you are dead on (I struggle to throw all under the bus especially on this platform where there is much love for melanotropins, haha* ;D ). Great topic btw. Early in my experimentation/research I would review data from MT-1 and PT-141, combined with a-MSH...weighing the unique risk assoc with MT-2 usage.
In the end I'm sure we're all here to understand each other's concerns, to understand the reasons why they choose for something like melanotan. How we can improve things, finding alternatives ( melitane, forskolin,....) and just make people being unhappy about their appearance happier
Thanks Guys! Its nice to be able to share meaningful experinces and have respectful dialogue, even when we dont agree on everything. Djen, you make a great point; thanks for reminding us that we are all here for the same reasons.
You can compare it with the use of cellphones when it comes to long term effects. We just cannot be sure but we don't stop using it because it makes our life more comfortable.
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You can compare it with the use of cellphones when it comes to long term effects. We just cannot be sure but we don't stop using it because it makes our life more comfortable.
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I wonder if there are any significant clinical trials to refute your hypothesis. LOL. Maybe in ten years there will be plausible contrary evidence. Nonetheless, even with plausible evidence, many of us may still choose to use the product. Just look at the evidence for the risks of tobacco use.
The Long-Term Use of Melanotan II for Tanning - Bill Roberts | Meso Rx
[b]Q] (MT-II) but nothing on long-term use. I’ve never been able to stay out in the sun as long as I’d like, and have never been able to get a really good tan. But I’m not interested in a temporary fix. How do I use MT-II long term, or is this just not a good idea? And in general, how do I dose it?”
A]Melanotan II works by stimulating the alpha-melanocyte receptor, which promotes formation of melanin in response to sun exposure. When a substantial amount of MT-II has been taken within recent “memory” of the skin cells, an individual tans as if he were a genetically darker type.
Some find MT-II unsuitable for them because of development of moles, or because of uneven skin darkening. But for most it works very well with no problems, including when used long term.
A possible additional side effect is greater tendency to developing an erection, typically beginning several hours after taking the drug. Depending on the individual, dosing may need to be at least 1 mg for this to occur. I’d recommend against exceeding 2 mg at a time. For those specifically seeking this effect, bremalanotide (PT-141) would be another option. It’s reported to share MT-II’s pro-erectile effect, but with no effect on tanning.
Melanotan II has an initial loading phase, and – if desired – a maintenance phase after that. Or, its effect can be allowed to slowly wear off over a period of months, and loading can be repeated.
Usually, 10-30 mg total use is required during the loading phase, with paler individuals requiring more than relatively darker individuals. It’s best to start with very low dosage, such as only 0.25 mg per day, and then work up if desired. Many can tolerate 2 mg/day, but it’s possible that risk increases with such use, and it usually should not be necessary to load up that fast. Even 0.5 mg/day will allow loading with 30 mg in only two months, or 1.0 mg/day will allow that much loading in just 30 days.
To maintain the same tanning ability, ongoing per-year usage after this needs to be about 2-3 times the loading dosage, as an estimate. So for example if you needed 30 mg of loading to get the result you want, to maintain it you might need about 60-90 mg total Melanotan II over the course of the year. You’d already have injected 30 mg of that, so there would be 30-60 mg (typically three to six vials) remaining to inject over the next 11 months.
You could be very precise and figure this as 2.72 – 5.45 mg/month or 0.09 – 0.18 mg/day. But there’s no need to do that. Instead, it would be fine to figure it as a vial per 2-4 months. Once starting on a vial, it could be injected at an amount such as 0.5 mg/day until the vial is finished.
This is easier than having to inject it at all the time, and gives equivalent results.
The frequency of starting maintenance vials can be varied according to personal judgment of effect. There’s no problem with underestimating, or even with going a year or more without maintenance, because it’s always easy to catch back up.
Of course, sun is still required to get a tan. MT-II facilitates tanning, but does not directly cause it.
Good posts on this subject. A little testy for a while but glad everyone pulled back a bit. Some members are more scientifically oriented than others. I don't include myself in that category. Please be patient and gentle with how you respond to those of us who are less educated on the subject. Thank you all for the great information.
I saw the article that Melanotan shared, posted on some steroid site a while back. It provides good general anecdotal information about MII. However, theres no significant objective scientific evidence that currently exists to determine either way, if it is safe or harmful. There are a lot of personal claims that it is safe, based on personal use. For some that may be enough, for others that may not be. One thing for sure is that it definitely induces melanogenesis. One other thing to keep in mind is that personal claims may sometimes be driven more by confirmation bias than objective inquiry, but that is not always the case.
One thing with MII that I believe requires much more research is the fact that it is a non-selective agonist for all MCR receptors, not just the MCR receptors in the skin. Particularly, it also targets the MCR receptors in the CNS system. I wonder what kind of longterm effects, if any, it may have on the brain and CNS system. I wonder if this why the scientific community is not interested in conducting any significant clinical trials for its tanning effects?
For me, I would like to see more scientific research to evaluate the longterm effects. Thats just me.
When there's no scientific research, it's all based on personal experiences.
I just hope the alternatives will more practical to use, so keep up the good work, JROD.
I can only speak for myself but in 6 years time everything is fine. What could it do to me in 30 years from now? I don't know but I also don't want to lose sleep over it, but that's personal once again. In the mean time medicine will have gone through a big evolution anyway.
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I wonder if this why the scientific community is not interested in conducting any significant clinical trials for its tanning effects?
For me, I would like to see more scientific research to evaluate the long term effects.
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How would you like to be in the control group? Not I....
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I think most of us would agree with you on that... but I am now more interested in alternative delivery routes and stability manipulation, especially for topical use.
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When there's no scientific research, it's all based on personal experiences.
I just hope the alternatives will more practical to use, so keep up the good work, JROD.
I can only speak for myself but in 6 years time everything is fine. What could it do to me in 30 years from now? I don't know but I also don't want to lose sleep over it, but that's personal once again. In the mean time medicine will have gone through a big evolution anyway.
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Very true. With a good reputable supplier, most would probably be in agreement with you. However, some may not. Probably a minority may not be willing to take the risk. For example, a skin type II that tans, may not be as motivated. Or a parent who is more concerned about raising their child may consider it an unnecessary risk to their health. Its ultimately based on personal opinion.
Me too, I wonder if one of the other alternatives the forskolin researcher are mentioning ( they didn't mention the names) is melitane. After 3 weeks and 2 days no results yet but maybe I compare it a bit too much with melanotan in terms of: after how long will it work?
As I mentioned before I once ordered the 20 percent forskolin once and mixed it with a couple of creams, had it done by a pharmacist as well. Most cream didn't work except for one that looked more like a gel based lotion. I noticed hairs popping up darker and my skin getting a bit darker as well. As it was a small batch I couldn't continue and that pharmacist never wanted to give me the formula used. That's why I wonder that you can purify the "cheaper" forskolin yourself?
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