Clinuvel's CV9900

[footsandwich]

I was on Clinuvels website today and noticed something called CV9900?

Is this effectively going to become melanotan 3? or is this melanotan 1/2 in a topical form?

"CUV9900 is an alpha-Melanocyte Stimulating Hormone (alpha-MSH) analogue which the company intends will complement Clinuvel's lead product SCENESSE® (afamelanotide 16mg). It belongs to the same family of molecules, known as melanocortins, as afamelanotide.

Recent research has shown that CUV9900 is a potent skin protectant. Clinuvel intends to launch CUV9900 in various new formulations. Formulation work has commenced and Clinuvel expects the first formulations to be available for clinical testing after the commercialisation of its lead product".


Does anyone have access to info regarding this or know what exactly it is?

Very exciting!

[Wes Diamoni]

What a good find! I'm interested to hear the kind of safety involved with it, will it be tested on people to ensure it's good for the masses? I hope to hear good things out of this.

[Oblivion]

It is topical and a different molecule than MT-1/2. MT-1 is 13 amino acids long I think, MT-2 is 9 (by my count), and CUV9900 is 6. Clinuvel doesn't release much information about it, but there is a joint venture with biotech lab Singapore to develop it in Asia. It is supposed to be for pediatric use in EPP (what Scenesse, which is MT-1 in implant form, is approved for in Europe in adults). Down the road they have plans for it in Vitiligo, and then it could be used off-label by anyone basically.

Unfortunately, the patent for it expires in 2024 and they haven't announced that it's any further than pre-clinical testing yet. In my opinion we could see something like what Abdel-Malek is researching at the University of Cincinnati make it to the market before this. Their molecule is only 4 amino acids long and should penetrate better than CUV9900. They would probably license it to a big pharma who could develop it quickly.

[Wes Diamoni]

I'm not too familiar with the chemical compositions of melanocortins, what does the number of amino acids have to do with it?

[footsandwich]

Thanks for the info Oblivion must look up the Abdel Malek peptide.

I could be wrong Wes from what iv'e read the larger molecule, meaning the more amino acid chains - the less effective it is at reaching the melanocytes through the skin. This is only a problem for topical formulations i think.

[Oblivion]

All I know is that it is for skin penetration too. http://healthnews.uc.edu/news/?/24818/ "To make it easier for the hormone to penetrate the fatty lipid layer of the skin, researchers reduced alpha-MSH from its original peptide chain of 13 amino acids to a chain of only four amino acids and then three to make it more effective at penetrating the skin to target the melanocytes."

It might affect what receptors it actives too, but that's just me guessing.

[TanTanPlease]

"

I was on Clinuvels website today and noticed something called CV9900?

Is this effectively going to become melanotan 3? or is this melanotan 1/2 in a topical form?

"CUV9900 is an alpha-Melanocyte Stimulating Hormone (alpha-MSH) analogue which the company intends will complement Clinuvel's lead product SCENESSE® (afamelanotide 16mg). It belongs to the same family of molecules, known as melanocortins, as afamelanotide.

Recent research has shown that CUV9900 is a potent skin protectant. Clinuvel intends to launch CUV9900 in various new formulations. Formulation work has commenced and Clinuvel expects the first formulations to be available for clinical testing after the commercialisation of its lead product".


Does anyone have access to info regarding this or know what exactly it is?

Very exciting!
"

I thought this was an "implant"

i.e. they give you a shot of some implant that slowing disolves over 2-3 weeks

I'm not sure if this is because of less sides, or because they want to make using it easier (don't need to dose everyday)

I also thought it was Melanotan I

[peptideguru]

"
I thought this was an "implant"

i.e. they give you a shot of some implant that slowing disolves over 2-3 weeks

I'm not sure if this is because of less sides, or because they want to make using it easier (don't need to dose everyday)

I also thought it was Melanotan I
"

SCENESSE, or as we know it afamelanotide/Melanotan 1 is a separate drug to CUV9900.


The original ideal for SCENESSE was a implant, but was thought to be invasive, so I'm pretty sure they were also developing a micro-needle patch (like the nicotine ones). No idea whether they worked as well - but hey, when you're chucking near $100m at it, you can probably afford to experiment a little.


CUV9900 I'm pretty sure is a related but different a-MSH agonist, the winning point, the peptide sequence is 1/3 of the size, and small enough to be carried transdermally.
That's the reason all of the MT1/MT2 topicals don't work - because they're just too large. You'd think if there was a way to do it, Clinuvel would have worked it out and saved themselves tens of millions of dollars.




As to the other comment about why;
Less sides, (constant low levels)
More effective, (doesn't drop to trace levels then rocket, then drop again)
Less invasive, (no twice daily injections)
Less maintenance, (stick a patch on a patient and then they come back 2 weeks later for another one)

[Hopeso2]

I just wonder if some peptide manufacturer Winkey for example could produce this so it would be available within the near future

[peptideguru]

I just wonder if some peptide manufacturer Winkey for example could produce this so it would be available within the near future

Nobody knows the sequence, if you find that out you can start inquiring about custom synthesis. Expect around $6000/g, ($60/10mg vial) with that likely being the minimum order.

[Hopeso2]

Wow thats interesting , unrealistic but interesting and the sequence no doubt being a closely guarded secret lol

[fabric]

interesting find.
I think MT2 is pretty good as it is right now. That said, it comes with some side effects which can be quite potent depending on the individual. It would be best if a way to stimulate the tan alone was found.

Even if we got a topical, i think an injection would be the way to go for me. Seems easier once you are used to it. A pill would be best but from my understanding, is pretty much impossible.
Very good to see more development is being done. Maybe one day we will reach a point where they discover a way to permanently "switch on" the melanin producing cells to preferred degrees for anyone, even those who cannot produce it naturally.

[Hopeso2]

For sure I agree , im unfortunately one those induviduals who cant tolerate M2 even at micro doses

[peptideguru]

For sure I agree , im unfortunately one those induviduals who cant tolerate M2 even at micro doses

Have you tried MT1 at all?

[Hopeso2]

Yep for sure im on M1 at the moment and its results are fairly good but you couldnt say dramatic. going to add Melitane just to see what happens

[Hopeso2]

Any guesstimate as to when AbdelMaleks peptide will be available ?

[poiuytr]

Pure speculation, could something similar to https://en.wikipedia.org/wiki/BMS-470,539 work? It seems that MT1/MT2 work by activating the melanocortin 1 receptor, and the activation of other receptors is unnecessary, and is where some of the unwanted side effects come from. Although, searching 'BMS-470539 tanning' yields no results, so I guess it's more complex than that.

[Hopeso2]

Im really interested in Abdel Maleks peptide , if anyone here has any information on its development or in paticular when it will be released id be really interested to know

[peptideguru]

Any guesstimate as to when AbdelMaleks peptide will be available ?

I'm not familiar with it, and don't have the time to research currently, but normally between a few year and tens of years.

If it's important to daily life for many people it'll be pushed along quicker. If it's less important, niche or cosmetic then the process is considerably longer.
If there's any issues during trials then it gets pushed back and pushed back until the effect outweighs the sides.

Chances are, if you don't suffer from a skin disorder (EPP/Vitiligo/etc) then you'll never be able to 'access' it.
Counterfeit (as in, not made by the patent holder) may appear around the more public trials or if any information gets leaked on the formation or the drug - when that will be nobody knows. It also depends if it's worth making - Scenesse/MT1 for example had lots of potential, and with MT2 currently on the market the new peptide would have to be stronger or considerably less side effects.
Initial runs of a new peptide are considerably more expensive than generic peptides though, so it will be out of the reach of any casual users for months-years depending on the reception of it.

[Hopeso2]

Oh ok peptideguru well I guess that answers that then , thanks