Brain Peptide
2012
Current combinations of surgical therapy, radiotherapy and chemotherapy regimens do not significantly improve long-term survival of the patients with malignant glioma. Cancer immunotherapy against malignant glioma is a potentially new therapeutic strategy that primes a patient's immune system to attack glioma cells.
Peptide-based vaccination appears promising as an approach to successfully induce an antineoplastic immune response, produce clinical response and prolong survival in patients with malignant glioma without major side effects. Clinical progresses are being reviewed in developing peptide-based vaccinations for malignant glioma.
Brain Cancer Vaccine* A new clinical research study at Roswell Park will test a first-of-its-kind cancer vaccine that may prove effective against many forms of solid-tumor cancers.
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Most existing vaccines are prepared from an attenuated version of the pathogen or from inactivated disease-causing organisms or a suitable part of it. However, often the antigen to which the immune system responds is a relatively small number of amino acids or protein peptides.
A possible alternative approach to immunization would therefore be to identify the peptide sequences that trigger a protective immune response and to use completely synthetic versions of these as the vaccine substance. Because they would be synthetic, there would be no risk of mutation or reversion, little or no risk of contamination by pathogenic or toxic substances, and chemical manipulation of the peptide structure could possibly increase stability and decrease unwanted side effects seen in the native sequence. The number of antigens prepared this way would also increase, substituting for microorganisms that grow poorly in culture, or exposing parts of the antigen that are not seen by the immune system during natural infection.
Due to the ease in sequencing new strains of microorganisms, peptide antigens could be rapidly modified to generate strain-specific responses. However, the approach is not without practical and theoretical difficulties. Often the antigenic epitope is not a simple sequence of amino acids, but a structure composed of various parts of the peptide sequence coming together to build a three-dimensional structure. Modelling of these structures will be needed to generate the correct antigenic site synthetically.
peptide vaccine are recently found most effective and promising tool in approaching malignant glioma has reduces side effects leading to cancers and shows better progress with its uses.
This is some of the best news I have heard all day about the fight of cancer. I hope there will be other research that has more immunity for other cancers in the future.
Wow this is amazing. Definitely some of the greatest news that I have heard of in a while! I do feel like this is a huge step in terms of medical development, so it will be interesting to see where this one goes.
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