Does that mean the* isopropyl alcohol and PG are the carriers for forskolin and the other ingredients are just to turn it into a gel or to give it some extra good smell?
Nice, so it would feel like some sort of serum that could be used for eyelashes, eyebrows as well?
In the past a pharmacist prepared me some forskolin serums and one of them looked gel based, after some time I noticed some hair darkening but I ran out of product and she couldn't make me another batch. Just never knew about the ingredients.
Do those penetrators evenly penetrate skin and hair?
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Nice, so it would feel like some sort of serum that could be used for eyelashes, eyebrows as well?
In the past a pharmacist prepared me some forskolin serums and one of them looked gel based, after some time I noticed some hair darkening but I ran out of product and she couldn't make me another batch. Just never knew about the ingredients.
Do those penetrators evenly penetrate skin and hair?
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You could modify it of course. I don't really have the free time to look into the specifics, but I'd imagine a quick browse on google for either 'gel thinkening', 'hair penetrators' and similar will return the results you're looking for.
Generally penetrators are different.
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On another note, the original forskolin experiment on the rats was very basic.
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Unless otherwise indicated, a crude extract of Coleus forskohlii root preparation was used as a working source of forskolin (ATZ Natural, Edgewater, NJ)18. Purified forskolin was purchased from Sigma-Aldrich Chemical Corporation (St. Louis, MO). All topical agents were prepared as a weight]"
When you google it, you find so many different penetrators. PG and ethanol should be good penetrators already but is adding an oil a good idea? You read olive oil, coconut oil,....but also stuff like DMI or emu oil. The question is: would throwing it into a mix give a stronger effect or could one extra ingredient make the other one work less well?
PS the next part doesn't seem like it's easy to do yourself at home:
The C. forskohlii extract-derived topical preparation was made by mixing the dry root powder (extract) with vehicle for 1h at room temperature on a stir plate with constant agitation. Next, the solution was centrifuged (10 min, room temperature, 2,000 x g) and the soluble portion (supernatant) was collected and filtered (0.45 µ cellulose acetate filter)
When you google it, you find so many different penetrators. PG and ethanol should be good penetrators already but is adding an oil a good idea? You read olive oil, coconut oil,....but also stuff like DMI or emu oil. The question is]"
Though I'd replied to this but apparently not! (must have backed out before sending it)
Additional penetrators normally work in synergy. The oils also make it nicer for daily application, I believe - they also have nice smells. (if you like coconut, anyway!)
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PS the next part doesn't seem like it's easy to do yourself at home]
The C. forskohlii extract-derived topical preparation was made by mixing the dry root powder (extract) with vehicle for 1h at room temperature on a stir plate with constant agitation. Next, the solution was centrifuged (10 min, room temperature, 2,000 x g) and the soluble portion (supernatant) was collected and filtered (0.45 µ cellulose acetate filter)
or doesn't it really matter?
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Doesn't everyone have a vibrating plate and centrifuge!? Me either.
I imagine you can substitute some of the processes, but account for them being less effective.
It doesn't make it easier. I thought mixing the powder with ethanol would just do the job.
I really want to figure this out as it's important. Would be a shame to have a less active product because you did something wrong.
The anabolics minds link didn't mention anything about centrifuges and stuff.
It's possible to get some organic substances to dissolve in water by dissolving it in ethanol, mixing that with water, and using some specialised Chemistry equipment to remove the ethanol again, but the reality is the concentration would be pretty low. If there are products out there which use forskolin, it's likely that they use this method, which explains it's low concentration.
That said, some organically-soluble compounds are also soluble in oils, so it couldn't hurt to try.
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Some comments from a scientist]
It's possible to get some organic substances to dissolve in water by dissolving it in ethanol, mixing that with water, and using some specialised Chemistry equipment to remove the ethanol again, but the reality is the concentration would be pretty low. If there are products out there which use forskolin, it's likely that they use this method, which explains it's low concentration.
That said, some organically-soluble compounds are also soluble in oils, so it couldn't hurt to try.
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Forskolin is soluble in Ethanol, Chloroform and DMSO. A couple other things too but you'll be paying more or they'll be harder to acquire.
Here is a list of organic solvents]Not sure if they'd all work with forskolin. Imagine some will be better than others.
The solvents seem to be drying and I would wanna use it near the eye.
The method he described to get rid of the ethanol afterwards seems to be a good one, might be a way to do that at home.
The thing is: forskolin needs to be dissolved first I suppose before it can start working. A good exercise for the scientists over here.
emulsion phase
emulsifying wax .8oz
extra virgin organic cocounut oil .2oz
extra virgin olive oil .2oz
sweet almond oil .2oz
BUT is it okay to replace the DMGE and or limonene by DMI? and just add coconut oil ( in order not to buy too much)
Is the emulsifying wax and sp thickener necessary to make it work?
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