Lose Weight and Improve Your Sex Life
Those two pitches account for approximately 95% of all spam, right? But what if you could manufacture one water soluble research peptide that promises to do both? Enter Melanotan tanning injections....

Although it sounds too good to be true, there may yet be such a substance]
Melanotan 2 reduction of appetite suppresion, the arcuate nucleus of the hypothalamus may play a central role. The arcuate has two populatons of neurons]
Are there any peptides that act directly at MC4-R? And what about sexual function? Where is that legit aphrodisiac weight loss supplement??
In contrast to the modest weight loss associated with short-term SSRI treatment, these antidepressant drugs are associated with high rates of sexual side effects. Enter PT-141 Bremelanotide.

Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB. (2004). Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction.

Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. (2004). Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra.

Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R. (2006). An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist.

Back in April, there was an article in The Observer Magazine and a post in Pharyngula about this compound. A good place to start if you really want to learn about MC4-R agonists is this article]Nargund RP, Strack AM, Fong TM. (2006). Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity.

Funniest lines from the article]* * If MC4R agonists induce spontaneous penile erections in men, this would represent a significant impediment to the development of compounds to treat obesity.

* * The non-selective melanocortin agonists, 1 and 3, have nausea and vomiting as adverse side-effects of melanotan use when administered to either subcutaneously or intranasally. Attempts to study whether the effects of these two structurally related molecules are mechanism-based have been limited.