There are major differences between the linear Melanotan One and the cyclic MT-II peptide.*
Which one is safer?* Melanotan One is your short answer and allure.*
The limited side effects associated with Melanotan One usage are appreciated by users.* Melanotan One does not cross the blood brain barrier (BBB).* For this reason this analogue has continued clinical trials. Cyclic analogues (MT-II) have a wide range of peripheral effects and systemic control are always going to pose issue in clinical use (weight loss, sexual desire, appetite suppression).* Developers would be faced with an almost impossible mission had they chosen to develop MT-II and place before regulatory authorities for approval.* Sides effects are more prevalent in Melanotan II users.* However, most choose Melanotan II over Melanotan One because it is a better value, tans more efficiently/effectively, effects the libido, etc.* Across the board, MT-II is superior to Melanotan One when it comes to photoprotection and tanning.* Furthermore MT-II has been shown to have an effect on body composition via the melanocortin system.
Melanotan One's peptide structure is very closely matched to alpha-melanocyte stimulating hormone (?-MSH). It specifically targets the melanocortin-1 receptor (MC1R) which is a single receptor responsible for skin color.* MT-II, on the other hand, is a shorter amino acid sequence which effects a range of melanocortin receptors (MC1R, MC3R, MC4R & MC5R).* This 'shotgun effect' agonism of the full spectrum of receptors results in effects that are only witnessed from MT-II.* Most notably, increases in sexual arousal that are due to MC3R & MC4R activation.* Melanocortin receptors show tissue-specific expression patterns, as well as different binding affinities.* The central melanocortin system plays a fundamental role in the control of feeding and body weight.* Melanotan One users want minimum side and peripheral effects with a focus on photoprotection.*
Melanotan One has a half life that lasts just minutes in the body.* Melanotan 2 is further reaching and lasts longer in the body.* It was recently found out that the pituitary gland is not what is responsible for a-MSH production, but the cites on the skin itself which triggers the release.* Dosing 1mg of either Melanotan One or Melanotan II peptide is quite super-physiological for the average caucasian.* Melanotan One yields subtle results while Melanotan II users reporting extreme results.
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