I bought my PT-141 from madisonjamesresearchchems.com before finding this forum, for whatever help that information may be.* I've seen no mention of them here so far, so I have no idea what their reputation is.
I'm very familiar with reconstituting lypholized injectables so had no issues adding 1 ml of BA water to the 10mg of powder in the vial I received.* The result was a nice clear solution that should be 10 mg/mL.* Therefore .1 mL of solution should be 1 mg of PT-141.* I know you all know this - I'm just clarifying that I "get it" as well.
I wanted to start cautiously (you can inject more, but you can't pull it out if you react badly) so the first subcutaneous injection I only injected .05 mL (which would be .5 mg of PT-141).* I kept a log of effects, observations, and times, and 9 minutes later my whole face/head was very flushed, like bright lobster red.* I figured that was a good sign that what I got wasn't just some placebo powder junk.* After about 2 hours and 15 minutes the flushing had completely subsided.
I tried to pay attention to my body closely for the remainder of the day -- looking for any signs of the oft-reported spontaneous erections, distracting thoughts, etc.* I never observed any such effects.
I stored the reconstituted vial in a dark desk drawer - at room temperature which is about 74 degress F.* As I used to do with other meds, storing it in the fridge would probably be a better plan (and others seem to say they do that as well).
I waited 24 hours from the first attempt to try a second attempt.* This time I injected .1 mL which would be 1 mg of PT-141.* About 7 minutes later the flushing set in, but it was not nearly as bright red (or hot feeling) as the .5 mg injection the day before.* I decided to take a nap.* At around the 45-minutes-elapsed mark I had a spontaneous erection that subsided quickly (about 2 minutes).* It was most likely unrelated to the PT-141 and was just due to the nap (judging from the timing).
I again tried to pay close attention to my body for the remainder of the day and at no time did I detect any effects on libido, nor any spontaneous erections, etc.
Some notes about me that may be relevant]
1. I am a pretty big dude - about 325 pounds.
2. I take two high blood pressure medications (lisinopril and bystolic) and my blood pressure is well controlled.* I tracked my BP post-injection and both the systolic and diastolic rose about 6 points - nothing to be concerned about.* I know some have reported marked increases in BP - perhaps my BP meds kept that from happening.
3. I usually do use 20 mg of tadalafil (Cialis) when I know I'll be having sex.* Prior to BP meds this was never needed, but the BP meds definitely have a negative effect.* 20 mg of tadalafil is usually enough to do the trick, but I have used as much as 40 mg.* I know 40 mg is the dose they use when prescribing it for pulmonary hypertension, so 40 mg isn't an insane dose.* I can get erections without the tadalafil - and sometimes they are very good ones - but generally I don't trust them to last through an extended sex romp so the tadalafil is always part of the party.
4. I'm 47 years old and surprisingly active for someone my size.
I'm wondering if my body size is relevant to the dosing.* The bigger the body the more blood you have and the smaller the ng/dl of any injected substance will be.* Any big guys/gals out there have any first-had experiences to share?
I'm willing to try 1.5 mg next, but I'm also wondering if it's possible that what I got from MJR just was a dud?* Given the very strong flush after the first dose, I would think not, but who knows.* I suppose the lesser flushing after the second dose (which was twice as large) could just be tachyphylaxis (as I have read people here say they developed a tolerance quickly -- but that quickly?!?!).
I've read some good posts naming some U.S. based suppliers - if anybody wants to recommend one that they specifically got great PT-141 from (here or via PM) that would be awesome.
Any other thoughts or relevant personal experiences are greatly appreciated.
I tried to be a good poster and read quite a bit before making my first post (this one).* If I asked anything stupid, or asked a well worn question answered 1000 times, please accept my apologies and kindly point me to the path of redemption.*
It could be the close attention that could be taking away from it, I find that relaxing is required and maybe the increased attention is taking from that.
I also find that it requires some stimulus, however small, to work properly.
I weigh about 115kg (253lbs), 1.5mg seems to be my ideal dose and an inset of 3-4 hours on average.
Normally I use it before going out for dinner, and can start to feel the effects by the end of the meal.
Welcome LabRat, thank you very much for the topic! Sorry to read that the stars have not yet aligned with your PT-141 experience. I concur with about all of your inferences and want you to keep hope alive.
Although I don't flush from melanotan peptides, I understand many do after the initial administration(s)...the supplier appears to have delivered a quality peptide and I don't question the storage. Given how the .5mg and 1mg dosages of PT141 (Bremelanotide) have treated you, I would continue to pace myself before dosing 1.5mg. If say next Friday afternoon/evening you were to dose 1mg again and do not feel or wake up to a unique state of arousal, dose another .5-1mg Saturday morning.
Have you considered dosing 5-10mg Cialis alongside PT-141?
An observation of mine is that melanotan 2 users who dose low with a high frequency experience the libido increases often share rave reviews. It puts a lot of pressure on the PT users who seek a targeted short term response. Further I theorize stress can interfere with results, not sure if there was anxiety present during your trial (assume it was not a large player at hand). Tom @ Labpeptides.net is on point with his .02 imho.
It could be the close attention that could be taking away from it, I find that relaxing is required and maybe the increased attention is taking from that.
I also find that it requires some stimulus, however small, to work properly.
I weigh about 115kg (253lbs), 1.5mg seems to be my ideal dose and an inset of 3-4 hours on average.
Normally I use it before going out for dinner, and can start to feel the effects by the end of the meal.
Tom
"
Thanks for the personal experience Tom.* In both of my initial trials I wasn't in any sort of stimulating setting, but of course porn is always available anytime and I didn't even have any particular urge to pull it up.* Lol.
I'm a little limited in my experimentation at this point because I need to avoid the flushed face being present while my wife is around.* She's not a very adventurous type and I would hear no end of her worry that I was going to kill myself with the stuff, etc.* So ideally I would do the injection around 2 or 3 hours before she got home so the face flush would be clear, and then hopefully the libido part kicks in an hour or two thereafter.
I'm not discouraged yet - I just want to guide my experimentation for best results.* Thanks again for the input.
"
Welcome LabRat, thank you very much for the topic! Sorry to read that the stars have not yet aligned with your PT-141 experience. I concur with about all of your inferences and want you to keep hope alive."
Thanks Melanotan.* I'm still encouraged to experiment. ]
"Although I don't flush from melanotan peptides, I understand many do after the initial administration(s)...the supplier appears to have delivered a quality peptide and I don't question the storage. Given how the .5mg and 1mg dosages of PT141 (Bremelanotide) have treated you, I would continue to pace myself before dosing 1.5mg. If say next Friday afternoon/evening you were to dose 1mg again and do not feel or wake up to a unique state of arousal, dose another .5-1mg Saturday morning.
Have you considered dosing 5-10mg Cialis alongside PT-141?"
I'll add some Cialis into the picture for my next test.* When I did my first and second test it had been 4 and 5 days respectively since I had any Cialis, so that definitely would make a difference in erections.* I find the Cialis usually has an effect for around 3 days for me.
I had 20 mg of Cialis yesterday (and no PT-141 since Saturday), so the Cialis should still be working for me today.* I was considering trying the PT-141 again today even though I realize I should probably wait a week.
"An observation of mine is that melanotan 2 users who dose low with a high frequency experience the libido increases often share rave reviews."
Is low dose, high frequency not a good plan for PT-141 due to rapidly becoming desensitized to it?* I'd think the proclivity for desensitization would be similar to the parent molecule (MT2).
"It puts a lot of pressure on the PT users who seek a targeted short term response. Further I theorize stress can interfere with results, not sure if there was anxiety present during your trial (assume it was not a large player at hand)."
Nah, no stress at all.* My mood is one of optimistic curiosity.* If it doesn't ever work, that's fine - I just want to give it the best chance to.* I'm also acting as guinea pig to figure this stuff out in case it might be useful to a friend whose wife could use a little boost in the libido department.* He doesn't even want to broach the topic with her until there is some sort of indication that it's worth it.
"Tom @ Labpeptides.net is on point with his .02 imho."
I really appreciate how active Tom is here on the forums and it sounds like their product has a great reputation.
"An observation of mine is that melanotan 2 users who dose low with a high frequency experience the libido increases often share rave reviews."
Is low dose, high frequency not a good plan for PT-141 due to rapidly becoming desensitized to it?* I'd think the proclivity for desensitization would be similar to the parent molecule (MT2).
I'll post my results as I go.* ]"
It is a good plan, the negative side effects from dosing too much (too quick) are primarily what the body desensitizes to (it takes much more effort to diminish the aphrodisiac properties). Thanks again LR, hope to hear of your home experience before long (good luck keeping it from the better half, too bad she isn't privy).
PT 141 has never given me a erection , MT 2 did when we first started but with use (low level) it quit working so I tried 141 and it was a dead end(have tried it from several different suppliers) also tadalafil has no effect on me even combined with 141 or MT2 , there are three stages to sex desire, arousal and orgasm,* problems can occur in any one of these some time physical (BHP) , psychosocial(stress, emotional )* or drug interactions ( beta blockers, antidepressants, ect). so LR you might be one who it doesn't work on , but my suggestion is to discuss the problem with the other half and calmly tell her about the alternatives +6to better sex ,you don't need to tell her that PT 141 is a experimental drug* but explain the sides that happen so if you do have them with her present she won't freek out.*
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