Hey guys just wondering if anyone knew the possible side effects or dangers of being being HIV Poz and taking MT2...
Been Poz for 2 years not on meds (personal choice)
Last T Cell count around 300
Taking 1mg every night, this is my first week
Just experiencing Nausea, facial flushing, oily skin & hair, Chest Pains (rare), and sometimes feels like I'm getting a common cold
I bought it from a site that has a buy 1 get 1 free deal, not sure if that should have been a warning sign for bad product
98% pure from elitepeptides.com
Last thing, if anyone has any info on hgh or other peptides/hormones that would be beneficial to me that would be greatly appreciated!
Commenting via a personal and non-medical background.
The sides you're stating are normal for that dose, if you're finding they can be a bit much there are a couple of things;
Either inject just before bed, when you wake up they should be gone - this can cause issues if you take a while to get to sleep or if your nausea sets in quickly, as you could be led there feeling nauseous for a while.
Alternatively, drop your dose to 500mcg, and see how that goes.
As to the other peptides, there are some that promote healing and repair, but I'm not sure whether they'll help in this situation, so won't say they do.
TB500 is an often used and quite well documented peptide, so you may want to look into that a little bit.
Other than that, I'm sure somebody here will know more, and hopefully more specific information that applies.
As with all medicines, if you feel like it is adversely affecting you, stop use and seek medical advice.
"
Commenting via a personal and non-medical background.
The sides you're stating are normal for that dose, if you're finding they can be a bit much there are a couple of things;
Either inject just before bed, when you wake up they should be gone - this can cause issues if you take a while to get to sleep or if your nausea sets in quickly, as you could be led there feeling nauseous for a while.
Alternatively, drop your dose to 500mcg, and see how that goes.
As to the other peptides, there are some that promote healing and repair, but I'm not sure whether they'll help in this situation, so won't say they do.
TB500 is an often used and quite well documented peptide, so you may want to look into that a little bit.
Other than that, I'm sure somebody here will know more, and hopefully more specific information that applies.
As with all medicines, if you feel like it is adversely affecting you, stop use and seek medical advice.
Tom
"
The fellow with the insulin pump and mt1 said too much crushed his immune
system. I would watch for signs that 1mg/day is doing anything but think it is
probably ok.
You can take an antihistimine to combat the sides.
I don't know much about HIV, but doesn't it lower your immune system? So does MT2.
To be honest, if you have HIV, I really REALLY think you should not even consider MT2. (And probably not MT1 either, although I'm less certain about the immune-inhibiting effects of that one.)
Some years ago, I had a log on Melanotan.org detailing my experiments with MT2 as a treatment to reduce chronic inflammation in my sinuses. Theoretically, the mechanism by which MT2 did this was by lowering your immune system.
I have a collection of studies on MT2 showing this effect. I can't seem to attach PDF files here, so I'll just paste the studies into the following posts...
New insights into the functions of alpha-MSH and related peptides in the
immune system.
* Luger TA,
* Scholzen TE,
* Brzoska T,
* Bohm M.
Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and
Immunobiology of the Skin, University of Munster, 48149 Munster, Germany.
luger@uni-muenster.de
There is a substantial body of evidence that the tridecapeptide alphamelanocyte-
stimulating hormone (alpha-MSH) functions as a mediator of
immunity and inflammation. The immunomodulating capacity of alpha-MSH is
primarily because of its effects on melanocortin receptor (MC-1R)-expressing
monocytes, macrophages, and dendritic cells (DCs). alpha-MSH downregulates
the production of proinflammatory and immunomodulating
cytokines (IL-1, IL-6, TNF-alpha, IL-2, IFN-gamma, IL-4, IL-13) as well as
the expression of costimulatory molecules (CD86, CD40, ICAM-1) on antigenpresenting
DCs. In contrast, the production of the cytokine synthesis inhibitor
IL-10 is up-regulated by alpha-MSH. At the molecular level, these effects of
alpha-MSH are mediated via the inhibition of the activation of transcription
factors such as NFkappaB. Not only alpha-MSH but also its C-terminal
tripeptide (alpha-MSH 11-13, KPV) was able to bind to MC-1R and to
modulate the function of APCs. In vivo, using a mouse model of contact
hypersensitivity (CHS) systemic and topical application of alpha-MSH or KPV
inhibited the sensitization and the elicitation phase of CHS and was able to
induce hapten-specific tolerance. To investigate the underlying mechanisms
of tolerance induction, we have performed in vivo transfer experiments.
Treatment of naive mice with bone marrow-derived immature haptenized and
alpha-MSH-pulsed DCs resulted in a significant inhibition of CHS.
Furthermore, tolerance induction was found to be mediated by the
generation of CTLA4(+) and IL-10-producing T lymphocytes. The potent
capacity of alpha-MSH to modulate the function of antigen-presenting cells
(APCs) has been further supported in another experimental approach. In
vitro, by activating APCs, alpha-MSH has been shown to modulate IgE
production by IL-4 and anti-CD40 stimulated B lymphocytes. Moreover, in a
murine model of allergic airway inflammation, systemic treatment with alpha-
MSH resulted in a significant reduction of allergen-specific IgE production,
eosinophil influx, and IL-4 production. These effects were mediated via IL-10
production, because IL-10 knockout mice were resistant to alpha-MSH
treatment. Therefore, therapeutic application of alpha-MSH or related
peptides (KPVs) as well as alpha-MSH/KPV-pulsed DCs may be a useful
approach for the treatment of inflammatory, autoimmune, and allergic
diseases in the future.
Targeting melanocortin receptors as a novel strategy to control inflammation.
* Catania A,
* Gatti S,
* Colombo G,
* Lipton JM.
Division of Internal Medicine, Ospedale Maggiore di Milano, Instituto di Ricovero e
Cura a Caraterre Scientifico, Milano, Italy. anna.catania@unimi.it
Adrenocorticotropic hormone and alpha-, beta-, and gamma-melanocytestimulating
hormones, collectively called melanocortin peptides, exert
multiple effects upon the host. These effects range from modulation of fever
and inflammation to control of food intake, autonomic functions, and
exocrine secretions. Recognition and cloning of five melanocortin receptors
(MCRs) has greatly improved understanding of peptide-target cell
interactions. Preclinical investigations indicate that activation of certain MCR
subtypes, primarily MC1R and MC3R, could be a novel strategy to control
inflammatory disorders. As a consequence of reduced translocation of the
nuclear factor kappaB to the nucleus, MCR activation causes a collective
reduction of the major molecules involved in the inflammatory process.
Therefore, anti-inflammatory influences are broad and are not restricted to a
specific mediator. Short half-life and lack of selectivity could be an obstacle
to the use of the natural melanocortins. However, design and synthesis of
new MCR ligands with selective chemical properties are already in progress.
This review examines how marshaling MCR could control inflammation.
PMID]
Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH.
* Lipton JM,
* Catania A.
Dept of Physiology, University of Texas Southwestern Medical Center at Dallas 75235-
9040, USA. LIPTON@UTSW.SWMED.EDU
alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous
neuroimmunomodulatory peptide that inhibits fever and all major forms of
experimental inflammation. In humans, concentrations of alpha-MSH are
increased at sites of inflammation, and in plasma in inflammatory disorders
and after infection of endotoxin. The effects of this 'anti-cytokine' peptide are
mediated through alpha-MSH receptors and regulatory circuits in
macrophages and neutrophils, and through descending neural antiinflammatory
pathways that originate from alpha-MSH receptors on neurons
within the brain.
Alpha-melanocyte stimulating hormone in modulation of inflammatory
reactions.
* Catania A,
* Gatti S,
* Colombo G,
* Lipton JM.
Internal Medicine Ospedale Maggiore di Milano IRCCS, Milano, Italy.
anna.catania@unimi.it
Although adrenal stimulatory effects of ACTH and pigmentary influences of
MSH have been known for decades, it has become clear only recently that
melanocortin peptides have multiple effects upon the host. These effects
range from modulation of fever and inflammation to control of food intake,
autonomic functions, and exocrine secretions. Recognition and cloning of
melanocortin receptors (MCRs) has greatly improved understanding of
peptide-target cell interactions. Synthetic melanocortins, with selective
affinities for specific MCRs, could be the basis for new classes of therapeutic
molecules. This review examines promising targets for a-MSH and closely
related peptides in inflammatory disorders.
PMID]
Modulation of the peripheral and central inflammatory responses by alphamelanocyte
stimulating hormone.
* Oktar BK,
* Alican I.
Marmara University School of Medicine, Department of Physiology, 81326,
Haydarpasa, Istanbul.
Inflammation, a localized response to tissue injury, and disorders
characterized by inflammation are difficult problems in clinical medicine. This
difficulty stems in large part from incomplete understanding of inflammatory
processes and their regulation. Recent development of knowledge of the role
of central nervous system and neuroendocrine system in host responses has
provided a new view of the capacity of neuronal and soluble mediators in
these systems to influence inflammation. One of these mediators is the
endogenous neuropeptide alpha-melanocyte stimulating hormone (alpha-
MSH), which is an N-acetyl tridecapeptide derived from the cleavage of a
larger precursor molecule, pro-opiomelanocortin (POMC). alpha-MSH is
widely distributed in tissues of higher organisms; it has been identified in the
pituitary, various brain regions, skin, circulation and other sites. The
neuropeptide alpha-MSH is important to the natural limitation of fever, which
is an early host response to endotoxin. In addition to its action within the
brain to reduce fever, alpha-MSH has potent and broad anti-inflammatory
effects in many forms of inflammation. This review will summarize the data
on the actions of the peptide on various aspects of peripheral and central
inflammation. On the basis of the data presented, we may think that the
anti-inflammatory actions of the peptide via peripheral and / or central
melanocortin receptors might put the peptide into practice therapeutically in
near future.
PMID]
Mechanisms of antiinflammatory action of the neuroimmunomodulatory
peptide alpha-MSH.
* Lipton JM,
* Catania A.
Department of Physiology, University of Texas Southwestern Medical Center at Dallas
75235-9040, USA. JLipto@MEDNET.SWMED.EDU
The antiinflammatory effects of alpha-melanocyte-stimulating hormone
(alpha-MSH) molecules, specifically alpha-MSH(1-13) and its COOH-terminal
tripeptide alpha-MSH(11-13), are well established. The peptides have been
effective in tests of all major models of inflammation, and more recent tests
have been extended to include experimental inflammatory bowel disease,
CNS ischemia/reperfusion injury, and bacterial endotoxin-induced
inflammation within the brain. The broad effectiveness of alpha-MSH
molecules in all major types of inflammation indicates that the peptides exert
actions that are very basic to the inflammatory process. Three general
mechanisms of antiinflammatory action of alpha-MSH molecules have been
identified]of inflammatory actions of, peripheral host cells; inhibition of peripheral
inflammation induced by actions on melanocortin receptors within the brain;
inhibition of CNS inflammation by local action of the peptides. It appears that
alpha-MSH molecules have multiple actions that modulate the primitive
inflammatory response.
PMID]
Natural and synthetic agonists of the melanocortin receptor type 3 possess
anti-inflammatory properties.
* Getting SJ,
* Allcock GH,
* Flower R,
* Perretti M.
The William Harvey Research Institute, London, England. S.J.Getting@mds.qmw.ac.uk
The effects of the natural and synthetic ligands for the melanocortin receptor
type 3 (MC3-R) have been evaluated in a murine model of experimental
gout. Systemic treatment of mice with gamma2-melanocyte-stimulating
hormone (gamma2-MSH) and the synthetic agonist MTII inhibited
accumulation of KC, interleukin-1 beta (IL-1beta), and PMN elicited by urate
crystals in the peritoneal cavity. In vitro, macrophage (Mo) activation,
determined as release of KC and IL-1beta, was inhibited by gamma2-MSH
and MTII. The mixed MC3/4-R antagonist SHU9119 prevented the inhibitory
actions of gamma2-MSH and MTII in vitro and in vivo, whereas the selective
MC4-R antagonist HS024 was without effect. Western blotting also showed
the presence of MC3-R protein on murine peritoneal Mo. Furthermore,
agonism at the MC3-R evoked accumulation of cAMP within the Mo, which
was inhibited by SHU9119. Thus, naturally occurring melanocortins, as well
as the synthetic long-acting compound MTII, activate MC3-R on peritoneal
Mo to inhibit the experimental inflammatory response.
"
I don't know much about HIV, but doesn't it lower your immune system? So does MT2.
To be honest, if you have HIV, I really REALLY think you should not even consider MT2. (And probably not MT1 either, although I'm less certain about the immune-inhibiting effects of that one.)
Some years ago, I had a log on m.org detailing my experiments with MT2 as a treatment to reduce chronic inflammation in my sinuses. Theoretically, the mechanism by which MT2 did this was by lowering your immune system.
I have a collection of studies on MT2 showing this effect. I can't seem to attach PDF files here, so I'll just paste the studies into the following posts...
"
Pretty much, HIV attacks T-helper Cells, which are required for your B cells to make antibodies.
A 'normal' T count is in the range of 500-1200/mm^3.
Thanks for the info and studies, I have to admit I've not seen any before that linked it to the immune system.
Either way, it should allow the OP to make an educated choice.
I've won't have time to read all of them (just skimmed them!), but does it mention anywhere about dosing? Imagine that could have quite an effect.
If they wish to take MT2 and it does lower the immune system then there may be a point at which they can find a balance. There are people who use 100mcg daily doses and still achieve a tan.
"
I don't know much about HIV, but doesn't it lower your immune system? So does MT2.
To be honest, if you have HIV, I really REALLY think you should not even consider MT2. (And probably not MT1 either, although I'm less certain about the immune-inhibiting effects of that one.)
Some years ago, I had a log on m.org detailing my experiments with MT2 as a treatment to reduce chronic inflammation in my sinuses. Theoretically, the mechanism by which MT2 did this was by lowering your immune system.
I have a collection of studies on MT2 showing this effect. I can't seem to attach PDF files here, so I'll just paste the studies into the following posts...
"
Welcome Pseudonym, are you able to elaborate on your certainty regarding MT2 lowering the immune system as this is news to me? I must agree that MT2 would not be on my short list of products when HIV+. How did your theory/experiment with MT2 as treatment to reduce inflammation fair, imagine it was a failure more so than success?
In terms of reducing sinus inflammation, I had mixed results. But then, my sinus situation was not at all straight-forward - I'd had repeated operations to remove polyps caused by the inflammation and/or infection, but whether the infectin caused the inflammation, or the inflammation caused the infection, I had no idea. If the inflammation came first, I also didn't know what was causing that - it may not have been caused by a hyper-sensitive immune system anyway.
However... I do know a severe asthmatic who swore that while he was on MT2 he was suddenly able to go for runs with stopping to puff on his inhaler.
30 milligrams in and only been in the tanning bed 4 times and seeing pretty good results.
My hands and buttox are the darkestis
Its a little weird as my buttox was the whitest part of my body but it also has the most fat and I belive that has something to do with it?* Not 100% sure though.
My hands were exposed to natural sun more then rest of me was as its always long sleeve and sweatshirt season where I live but they are very nice color and hope with time and sun blocking my hands & butt that the rest of my body will catch up.
I've been using my self tanner ( St. Tropes from Sephora )* to match my arms and hands and it does a great job.
Looking good, my hands are a bit darker than that, but I took a* hella lot.
I skipped some tanning sessions and been off the mt2 for a couple weeks.
I just got a uv lamp to use at home and have 18 level 3 tans left on pkg.
I also have about 100mg of mt2 in fridge. I'm going to see what I can do w/o
any more mt in the next couple weeks. Then probably hit the mt for another
loading etc.
Would like to be loaded and tanning / tanned before Jan when I'll be in Fla.
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