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  1. #1 23rd August 2014 
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    Anyone ever tried DMSO?

    Dimethyl Sulfoxide DMSO is an industrial solvent and aka "horse liniment"
    I have heard various people over the years who use it for arthritic and
    other treatments, and also heard that it carries anything on the skin
    surface (good or bad) into the blood stream. (ie some people have
    mixed it with poison such as cyanide and killed people with it.)
    If it could carry MT2 into blood, as long as the site was sterile first
    it could be a good way to do injectionless application.

  2. #2 23rd August 2014 
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    Re: Anyone ever tried DMSO?

    There are a lot of safety issues involved in using DMSO.
    It is also a neurotoxin at low concentrations and causes burning of the skin among other reaction.

    It could be possible for some people to use it and it is readily available on eBay.* As an individual you'll need to be careful in its use. As a company, I doubt we'll be able to due to those implications.

    Tom
  3. #3 23rd August 2014 
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    Re: Anyone ever tried DMSO?

    "
    There are a lot of safety issues involved in using DMSO.
    It is also a neurotoxin at low concentrations and causes burning of the skin among other reaction.

    It could be possible for some people to use it and it is readily available on eBay.* As an individual you'll need to be careful in its use. As a company, I doubt we'll be able to due to those implications.

    Tom
    "
    Ya, more reading seems to say it could work (won't mess up the peptide). And I'm led to believe that this is how many transdermal
    patch systems work. Would need to be pharm grade (or pet?).
    And clean the surface well with something that is antiseptic and leaves
    no residue that could be carried through with the dmso.
    I was wondering if it was applied at the same site over and over if the
    site would end up with a pigment concentration or not. Seems like it
    could.
  4. #4 23rd August 2014 
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    Re: Anyone ever tried DMSO?

    My understanding was that MT would become systemic upon entry to the body and shouldn't cause localised issues. There is potential that it will be slightly darker at the absorption site, like most people's stomachs are slightly darker die to the increased concentration there.
    Perhaps a rota of where to apply it could work, as you're not limited to fatty areas.
  5. #5 23rd August 2014 
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    Re: Anyone ever tried DMSO?

    "
    My understanding was that MT would become systemic upon entry to the body and shouldn't cause localised issues. There is potential that it will be slightly darker at the absorption site, like most people's stomachs are slightly darker die to the increased concentration there.
    Perhaps a rota of where to apply it could work, as you're not limited to fatty areas.
    "
    I was thinking making an area darker as a feature not a bug. Sometimes skin can
    get lighter spots or patches and this might let them focus some additional MSH
    treatment there.
  6. #6 23rd August 2014 
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    Re: Anyone ever tried DMSO?

    Perhaps one of the localised topicals would be suitable here. I'm not entirely sure about the properties of DMSO or how Melitane or forskolin become active. It may be an option, however.
  7. #7 25th August 2014 
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    Re: Anyone ever tried DMSO?

    "
    Perhaps one of the localised topicals would be suitable here. I'm not entirely sure about the properties of DMSO or how Melitane or forskolin become active. It may be an option, however.
    "
    So I bought some roll-on bottle dmso (3oz).
    My plan is to put 100u into a 10mg mt2 vial. (or maybe 50u)
    Then rub in 5 or 10u (1mg mt2) on a specific area a number of times (back of one
    hand or something).
    Will try this as part of loading phase, and then again once I'm out of loading as
    a way to maintain / increase color.
  8. #8 25th August 2014 
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    Re: Anyone ever tried DMSO?

    Sounds like a good plan, let us know how you get on!
    Imagine you'll know from the outset by whether you get sides.

    Although with your history you may not experience them due to previous intensive use.
  9. #9 25th August 2014 
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    Re: Anyone ever tried DMSO?

    "
    Sounds like a good plan, let us know how you get on!
    Imagine you'll know from the outset by whether you get sides.

    Although with your history you may not experience them due to previous intensive use.
    "
    I always get sides (if I take enough) where _enough_ might be 3mg.
    I usually just get the 'stretchies' and not much else.
    I think for the loading phase I'll be alternating between sub-q and DMSO.
  10. #10 25th August 2014 
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    Re: Anyone ever tried DMSO?

    May make determining the efficiency of the DMSO part difficult, but it will be an interesting test all the same!

    I imagine sides won't be a brilliant indicator then, as if it takes 3mg subQ then it may take as much as double that (as with nasal at 50%) to see sides.
  11. #11 25th August 2014 
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    Re: Anyone ever tried DMSO?

    "
    May make determining the efficiency of the DMSO part difficult, but it will be an interesting test all the same!

    I imagine sides won't be a brilliant indicator then, as if it takes 3mg subQ then it may take as much as double that (as with nasal at 50%) to see sides.
    "
    That's what I'm saying, I'll ramp up to as much as 3mg with DMSO, alternating
    from same batch of MT2 sub-q to see which gives sides or not.
    Not very scientific but if I get similar via dmso as to sub-q then the DMSO would
    be more than the 54% number for nasal that I keep seeing bantered about.
    I'm quite interested to see if there is a localized effect like other topicals.
    If it's half as effective as sub q, then it's break even with nasal but could be a
    win for those that want to focus more tan on their arms or other body parts.
  12. #12 25th August 2014 
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    Re: Anyone ever tried DMSO?

    Not entirely scientific but it's very difficult to be with testing like this - there are far too many variables.

    54 is a very specific number! We normally use 50 for the fact it generally takes about twice as much to see similar effects. Some people believe it to be as much as 70-80%, others 20. But then on a similar note some people tan better on their second run and some worse! Things like weight, UV exposure and time of exposure vary so much you really can't pin it down.
  13. #13 26th August 2014 
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    Re: Anyone ever tried DMSO?

    "
    Not entirely scientific but it's very difficult to be with testing like this - there are far too many variables.

    54 is a very specific number! We normally use 50 for the fact it generally takes about twice as much to see similar effects. Some people believe it to be as much as 70-80%, others 20. But then on a similar note some people tan better on their second run and some worse! Things like weight, UV exposure and time of exposure vary so much you really can't pin it down.
    "
    Yup, apples being apples, I'm going into 3rd or 4th (lost count) run.
    Used this supplier before but whos to say the batch is same etc.
    I plan on testing via sub-q to see where the stretchies come in, then
    titrate via DMSO to reach same feeling on the next day or so.
    My first run was meh, but I was pretty white. Next was good and last
    jan/feb was awesome. I have always used significant uv, usually starting near the end of loading phase (7-10days).
  14. #14 20th September 2014 
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    Re: Anyone ever tried DMSO?

    Wow, time goes fast!


    Almost a month since the last update, did you get chance to experiment with this?


    Tom
  15. #15 20th September 2014 
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    Re: Anyone ever tried DMSO?

    "
    Wow, time goes fast!


    Almost a month since the last update, did you get chance to experiment with this?


    Tom ]"
    Yes, no result at all.
    Blew 3 vials on trials.
    No sides, no local tanning, nothing.
    Could be fake Mt2, or fake dmso?
    I really expected better.
  16. #16 20th September 2014 
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    Re: Anyone ever tried DMSO?

    Ah, that's a bit disappointing! Thanks for the update though.
    I doubt it's fake for either of them. Not too sure on the production of DMSO but it isn't really a high cost product, so probably not worth the work.

    It could be that even DMSO isn't a suitable carrier on its own. The peptide does offer some interesting properties that stops it from penetrating the skin.
    We do know that it is possible though, as there have been clinical trial reports on the subject.

    Unfortunately, good guesses and stabs in the dark don't compete with multi-million dollar development and specialised scientists.
    Hopefully something is found soon but it's probably not worth waiting on as it'll be a secret worth keeping!
  17. #17 21st September 2014 
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    Re: Anyone ever tried DMSO?

    "
    "
    Wow, time goes fast!


    Almost a month since the last update, did you get chance to experiment with this?


    Tom ]"
    Yes, no result at all.
    Blew 3 vials on trials.
    No sides, no local tanning, nothing.
    Could be fake Mt2, or fake dmso?
    I really expected better.
    "

    Did you notice any unusual taste when you applied the DMSO to your skin? Pure DMSO is colorless and odorless, but many people report a garlic-like taste after they apply it to the skin.
  18. #18 21st September 2014 
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    Re: Anyone ever tried DMSO?

    "
    "
    "
    Wow, time goes fast!


    Almost a month since the last update, did you get chance to experiment with this?


    Tom ]"
    Yes, no result at all.
    Blew 3 vials on trials.
    No sides, no local tanning, nothing.
    Could be fake Mt2, or fake dmso?
    I really expected better.
    "

    Did you notice any unusual taste when you applied the DMSO to your skin? Pure DMSO is colorless and odorless, but many people report a garlic-like taste after they apply it to the skin.
    "
    Didn't notice, but never had that with any med.
    What I bought was a "roll on" that turned out to be some kinda jell inside.
    Sucked because it was too thick to pull into syringe so I had to uncap the vial
    and squirt some in, making measurements very sketchy.
  19. #19 16th November 2014 
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    Re: Anyone ever tried DMSO?

    forskolin is soluble in DMSO, I wonder if diluted with water and something like DMI, maybe it might be a better match than alcohol.
  20. #20 16th November 2014 
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    Re: Anyone ever tried DMSO?

    It sounds neat, my tests with mt2 were inconclusive, there's a chance my mt was
    fake or much weaker than it should be. I did get very tan with it though.
    I'm about to combine methoxsalen with mt2 and uv.. that should be fun.