Re: Melanoma associated with the use of melanotan-II.
This observation brings attention to the potential risk of melanoma related to the use of the cyclic ?-MSH analogue MT-II. The drug is unlicensed and incompletely tested, and the extent and types of adverse effects are unknown. Moreover MT-II is often used for merely cosmetic purposes by young people attending fitness studios.
The use of MT-II is often combined with the intense use of tanning beds, well established as a substantial risk factor for cutaneous melanoma.
In our case the close temporal relationship between MT-II injections and clinical growth and darkening of a melanoma points to a possible association.
The plausibility of a real causal association between MT-II and melanoma is however debatable. In vivo studies and studies in murine models have not shown any carcinogenic effect of the linear ?-MSH analogue MT-I. Investigations on the naturally occurring ?-MSH have shown multiple functions of the hormone. On the one hand, studies have proven ?-MSH to be anticarcinogenic with tumour suppressor effects, but on the other hand, research on melanoma cells in addition indicates a pro-invasive effect of ?-MSH, thus enabling the melanoma cells to evade immune surveillance
When it comes to MT-II, however, the true biological potential of the substance remains unknown.
Physicians should be aware that MT-II has become a part of the tanning culture in certain subpopulations. Our observation indicates a possible association between MT-II and melanoma, but larger studies are needed to substantiate this linkage.
Re: Melanoma associated with the use of melanotan-II.
The story is about a woman having used it for 3 weeks. Some of us have been using high dosages constantly for 10 years. You don't know if there's a history of skin cancer in her family, how often she used tanning beds before using melanotan. I'm not saying we should take it for granted but it's 1 story and because the drug is unlicensed people tend to see it as the biggest factor. IMHO
Re: Melanoma associated with the use of melanotan-II.
Hi Cees , do you have any link to the text I mark in red ?
"
This observation brings attention to the potential risk of melanoma related to the use of the cyclic ?-MSH analogue MT-II. The drug is unlicensed and incompletely tested, and the extent and types of adverse effects are unknown. Moreover MT-II is often used for merely cosmetic purposes by young people attending fitness studios.
The use of MT-II is often combined with the intense use of tanning beds, well established as a substantial risk factor for cutaneous melanoma.
In our case the close temporal relationship between MT-II injections and clinical growth and darkening of a melanoma points to a possible association.
The plausibility of a real causal association between MT-II and melanoma is however debatable. In vivo studies and studies in murine models have not shown any carcinogenic effect of the linear ?-MSH analogue MT-I. Investigations on the naturally occurring ?-MSH have shown multiple functions of the hormone. On the one hand, studies have proven ?-MSH to be anticarcinogenic with tumour suppressor effects, but on the other hand, research on melanoma cells in addition indicates a pro-invasive effect of ?-MSH, thus enabling the melanoma cells to evade immune surveillance
When it comes to MT-II, however, the true biological potential of the substance remains unknown.
Physicians should be aware that MT-II has become a part of the tanning culture in certain subpopulations. Our observation indicates a possible association between MT-II and melanoma, but larger studies are needed to substantiate this linkage.
"
As far as I know alpha-MSH stimulation has anti invasive effects on Melanoma ( see Links below)]
http://www.ncbi.nlm.nih.gov/pubmed/19641225
http://www.ncbi.nlm.nih.gov/pubmed/14612916
I will be very interested to read something telling the opposite.
Re: Melanoma associated with the use of melanotan-II.
@RIURAO: I thought so too. It's just one case. A young woman getting skin cancer and she happened to be on melanotan for 3 weeks. So many other people get skin cancer without having been on melanotan.
Re: Melanoma associated with the use of melanotan-II.
"
Hi Cees , do you have any link to the text I mark in red ?
"
This observation brings attention to the potential risk of melanoma related to the use of the cyclic ?-MSH analogue MT-II. The drug is unlicensed and incompletely tested, and the extent and types of adverse effects are unknown. Moreover MT-II is often used for merely cosmetic purposes by young people attending fitness studios.
The use of MT-II is often combined with the intense use of tanning beds, well established as a substantial risk factor for cutaneous melanoma.
In our case the close temporal relationship between MT-II injections and clinical growth and darkening of a melanoma points to a possible association.
The plausibility of a real causal association between MT-II and melanoma is however debatable. In vivo studies and studies in murine models have not shown any carcinogenic effect of the linear ?-MSH analogue MT-I. Investigations on the naturally occurring ?-MSH have shown multiple functions of the hormone. On the one hand, studies have proven ?-MSH to be anticarcinogenic with tumour suppressor effects, but on the other hand, research on melanoma cells in addition indicates a pro-invasive effect of ?-MSH, thus enabling the melanoma cells to evade immune surveillance
When it comes to MT-II, however, the true biological potential of the substance remains unknown.
Physicians should be aware that MT-II has become a part of the tanning culture in certain subpopulations. Our observation indicates a possible association between MT-II and melanoma, but larger studies are needed to substantiate this linkage.
"
As far as I know alpha-MSH stimulation has anti invasive effects on Melanoma ( see Links below)]
http://www.ncbi.nlm.nih.gov/pubmed/19641225
http://www.ncbi.nlm.nih.gov/pubmed/14612916
I will be very interested to read something telling the opposite.
"
Alpha-melanocyte stimulating hormone (?-MSH) arises from the proteolytic cleavage of proopiomelanocortin (POMC) and is the most potent naturally occurring melanotropic peptide. The biological effects of ?-MSH are mediated via melanocortin receptors (MCRs), which are expressed in virtually every cutaneous cell type. ?-MSH has pleiotrophic functions including the modulation of a wide range of inflammatory stimuli such as proinflammatory cytokines, adhesion molecules and inflammatory transcription factors. All of the former would be consistent with a cytoprotective role for this hormone in protecting skin cells from exogenous stress, as would occur following UV exposure or exposure to agents inducing inflammation or oxidative stress. In addition to actions on normal skin cells it also modulates both cutaneous and uveal melanoma cell behavior. With respect to melanoma, ?-MSH is intriguing as studies have shown that while ?-MSH has the potential to retard metastatic spread (by reducing cell migration and invasion) it is also capable of reducing the ability of the immune system to detect tumor cells (by down regulating adhesion molecules that would normally assist in immune cell interaction with melanoma cells). This review considers the evolving biology of ?-MSH and discusses its role in man that extend far beyond pigmentation of skin melanocytes, suggesting that the detoxifying role of ?-MSH in inducing melanogenesis is only one aspect of the stress-coping role of this hormone. Indeed melanoma cells may owe at least some of their success to the ‘protective’ role of ?-MSH.
Re: Melanoma associated with the use of melanotan-II.
"
"
Hi Cees , do you have any link to the text I mark in red ?
"
This observation brings attention to the potential risk of melanoma related to the use of the cyclic ?-MSH analogue MT-II. The drug is unlicensed and incompletely tested, and the extent and types of adverse effects are unknown. Moreover MT-II is often used for merely cosmetic purposes by young people attending fitness studios.
The use of MT-II is often combined with the intense use of tanning beds, well established as a substantial risk factor for cutaneous melanoma.
In our case the close temporal relationship between MT-II injections and clinical growth and darkening of a melanoma points to a possible association.
The plausibility of a real causal association between MT-II and melanoma is however debatable. In vivo studies and studies in murine models have not shown any carcinogenic effect of the linear ?-MSH analogue MT-I. Investigations on the naturally occurring ?-MSH have shown multiple functions of the hormone. On the one hand, studies have proven ?-MSH to be anticarcinogenic with tumour suppressor effects, but on the other hand, research on melanoma cells in addition indicates a pro-invasive effect of ?-MSH, thus enabling the melanoma cells to evade immune surveillance
When it comes to MT-II, however, the true biological potential of the substance remains unknown.
Physicians should be aware that MT-II has become a part of the tanning culture in certain subpopulations. Our observation indicates a possible association between MT-II and melanoma, but larger studies are needed to substantiate this linkage.
"
As far as I know alpha-MSH stimulation has anti invasive effects on Melanoma ( see Links below)]
http://www.ncbi.nlm.nih.gov/pubmed/19641225
http://www.ncbi.nlm.nih.gov/pubmed/14612916
I will be very interested to read something telling the opposite.
"
Alpha-melanocyte stimulating hormone (?-MSH) arises from the proteolytic cleavage of proopiomelanocortin (POMC) and is the most potent naturally occurring melanotropic peptide. The biological effects of ?-MSH are mediated via melanocortin receptors (MCRs), which are expressed in virtually every cutaneous cell type. ?-MSH has pleiotrophic functions including the modulation of a wide range of inflammatory stimuli such as proinflammatory cytokines, adhesion molecules and inflammatory transcription factors. All of the former would be consistent with a cytoprotective role for this hormone in protecting skin cells from exogenous stress, as would occur following UV exposure or exposure to agents inducing inflammation or oxidative stress. In addition to actions on normal skin cells it also modulates both cutaneous and uveal melanoma cell behavior. With respect to melanoma, ?-MSH is intriguing as studies have shown that while ?-MSH has the potential to retard metastatic spread (by reducing cell migration and invasion) it is also capable of reducing the ability of the immune system to detect tumor cells (by down regulating adhesion molecules that would normally assist in immune cell interaction with melanoma cells). This review considers the evolving biology of ?-MSH and discusses its role in man that extend far beyond pigmentation of skin melanocytes, suggesting that the detoxifying role of ?-MSH in inducing melanogenesis is only one aspect of the stress-coping role of this hormone. Indeed melanoma cells may owe at least some of their success to the ‘protective’ role of ?-MSH.
"
Very interesting, never read something related before.
In any case it would be neccesary to see what is stronger (or at least quantify) , avoid metastasis in an pre existing Melanoma or reducing the detection properties of the Inmune System becouse as you know the self life of the usual* Melanotan dosage in this cases is always below 2-3 hous /day, don´t really believe that it would be enought prove* to know if there is a relationship between Melanoma and the Melanotan Usage.
Under my opinion and as I said in other forums, the Melanoma is already in the body prior to the usage of Melanotan, and the Melanotan is the way to colour invisible melanomas, in most of the cases. But this is only an opinion.
After all those years in Melanotan I have read a few articles about people with Melanoma after Melanotan usage, and in all this cases, there were always an existing history of tanning bed usage prior to the use of melanotan, and I have never read in this former cases in where the Melanoma had spread to the body , they always talk about located Melanoma and even Melanocitic Lesions that could be compatible with Melanoma but still uncorfirmed by pathological anatomy...* I dont know if it is becouse there is not a tracing of the patient or what.
Re: Melanoma associated with the use of melanotan-II.
"
"
"
Hi Cees , do you have any link to the text I mark in red ?
"
This observation brings attention to the potential risk of melanoma related to the use of the cyclic ?-MSH analogue MT-II. The drug is unlicensed and incompletely tested, and the extent and types of adverse effects are unknown. Moreover MT-II is often used for merely cosmetic purposes by young people attending fitness studios.
The use of MT-II is often combined with the intense use of tanning beds, well established as a substantial risk factor for cutaneous melanoma.
In our case the close temporal relationship between MT-II injections and clinical growth and darkening of a melanoma points to a possible association.
The plausibility of a real causal association between MT-II and melanoma is however debatable. In vivo studies and studies in murine models have not shown any carcinogenic effect of the linear ?-MSH analogue MT-I. Investigations on the naturally occurring ?-MSH have shown multiple functions of the hormone. On the one hand, studies have proven ?-MSH to be anticarcinogenic with tumour suppressor effects, but on the other hand, research on melanoma cells in addition indicates a pro-invasive effect of ?-MSH, thus enabling the melanoma cells to evade immune surveillance
When it comes to MT-II, however, the true biological potential of the substance remains unknown.
Physicians should be aware that MT-II has become a part of the tanning culture in certain subpopulations. Our observation indicates a possible association between MT-II and melanoma, but larger studies are needed to substantiate this linkage.
"
As far as I know alpha-MSH stimulation has anti invasive effects on Melanoma ( see Links below)]
http://www.ncbi.nlm.nih.gov/pubmed/19641225
http://www.ncbi.nlm.nih.gov/pubmed/14612916
I will be very interested to read something telling the opposite.
"
Alpha-melanocyte stimulating hormone (?-MSH) arises from the proteolytic cleavage of proopiomelanocortin (POMC) and is the most potent naturally occurring melanotropic peptide. The biological effects of ?-MSH are mediated via melanocortin receptors (MCRs), which are expressed in virtually every cutaneous cell type. ?-MSH has pleiotrophic functions including the modulation of a wide range of inflammatory stimuli such as proinflammatory cytokines, adhesion molecules and inflammatory transcription factors. All of the former would be consistent with a cytoprotective role for this hormone in protecting skin cells from exogenous stress, as would occur following UV exposure or exposure to agents inducing inflammation or oxidative stress. In addition to actions on normal skin cells it also modulates both cutaneous and uveal melanoma cell behavior. With respect to melanoma, ?-MSH is intriguing as studies have shown that while ?-MSH has the potential to retard metastatic spread (by reducing cell migration and invasion) it is also capable of reducing the ability of the immune system to detect tumor cells (by down regulating adhesion molecules that would normally assist in immune cell interaction with melanoma cells). This review considers the evolving biology of ?-MSH and discusses its role in man that extend far beyond pigmentation of skin melanocytes, suggesting that the detoxifying role of ?-MSH in inducing melanogenesis is only one aspect of the stress-coping role of this hormone. Indeed melanoma cells may owe at least some of their success to the ‘protective’ role of ?-MSH.
"
Very interesting, never read something related before.
In any case it would be neccesary to see what is stronger (or at least quantify) , avoid metastasis in an pre existing Melanoma or reducing the detection properties of the Inmune System becouse as you know the self life of the usual* Melanotan dosage in this cases is always below 2-3 hous /day, don´t really believe that it would be enought prove* to know if there is a relationship between Melanoma and the Melanotan Usage.
Under my opinion and as I said in other forums, the Melanoma is already in the body prior to the usage of Melanotan, and the Melanotan is the way to colour invisible melanomas, in most of the cases. But this is only an opinion.
After all those years in Melanotan I have read a few articles about people with Melanoma after Melanotan usage, and in all this cases, there were always an existing history of tanning bed usage prior to the use of melanotan, and I have never read in this former cases in where the Melanoma had spread to the body , they always talk about located Melanoma and even Melanocitic Lesions that could be compatible with Melanoma but still uncorfirmed by pathological anatomy...* I dont know if it is becouse there is not a tracing of the patient or what.
"
there is still a lack of proper research, so hopefully there will be some updates soon.
melanomas are still found in the low and high skintypes, why it exactly happen is still unknown... there are theories but its not clear
i still have to say that when on mt1/2 its ridiculus to over exposure uv rays,even if you dont burn, and also you should still use a good spf when sunbathing it is not a replacement of a good sun blocking lotion...
Re: Melanoma associated with the use of melanotan-II.
Did you read about the polypodium leucotomus extract and its properties as an oral* SFP ?
Really very interesting not only as an oral SFP but as its anticarcinogenic properties and in skin deseases .
Re: Melanoma associated with the use of melanotan-II.
"
http://www.ncbi.nlm.nih.gov/pubmed/24355990
Another story without evidence or something to worry about?
"
your right about this. The article is obviously biased because the authors do not differentiate between sun exposure and Melanotan Use. The claim is not supported by evidence because this client's melanoma could have been attributed to excessive UV exposure.
Re: Melanoma associated with the use of melanotan-II.
Recently published study about Scenesse (MT1) for treatment of EPP (Erythropoietic Protoporphyria)
Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria
G. Biolcati1, E. Marchesini2, F. Sorge1, L. Barbieri1, X. Schneider-Yin3 andE.I. Minder3,*
DOI]
Free access]
http://onlinelibrary.wiley.com/doi/10.1111/bjd.13598/pdf
"Few reports on induction of either
atypical naevi or melanoma by illegal internet-distributed products containing alpha-MSH analogs
usually document a time span of a few weeks between the first dose of the illegal
product and the detection of the serious diseases30-33. The fast manifestation indicates that
the serious condition likely was present before the application of the illegal product and was
unmasked by the pigmentation enhancing effect of the alpha-MSH analog. This is consistent
with the risk profile of users of illegal products for tanning purposes, since these individuals
are more likely than the general population to expose themselves to harmful doses of intense
UV irradiation by frequent and prolonged sun exposure or the use of tanning salons34"
This is a very strong statement concerning the ability of Scenesse, or other MCR1 agonists like MT2, to detect melanomas at an early stage due to the pigmentation effect.
Many melanomas arise suddenly. A black tiny mole suddenly appears on the skin and changes consistently over a short period of time. Obviously these "sleeping" melanomas aren't colored. However, they got colored and visible by the melanocortins, making them detectable by dermatologists.
Re: Melanoma associated with the use of melanotan-II.
"
Recently published study about Scenesse (MT1) for treatment of EPP (Erythropoietic Protoporphyria)
Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria
G. Biolcati1, E. Marchesini2, F. Sorge1, L. Barbieri1, X. Schneider-Yin3 andE.I. Minder3,*
DOI]
Free access]
http://onlinelibrary.wiley.com/doi/10.1111/bjd.13598/pdf
"Few reports on induction of either
atypical naevi or melanoma by illegal internet-distributed products containing alpha-MSH analogs
usually document a time span of a few weeks between the first dose of the illegal
product and the detection of the serious diseases30-33. The fast manifestation indicates that
the serious condition likely was present before the application of the illegal product and was
unmasked by the pigmentation enhancing effect of the alpha-MSH analog. This is consistent
with the risk profile of users of illegal products for tanning purposes, since these individuals
are more likely than the general population to expose themselves to harmful doses of intense
UV irradiation by frequent and prolonged sun exposure or the use of tanning salons34"
This is a very strong statement concerning the ability of Scenesse, or other MCR1 agonists like MT2, to detect melanomas at an early stage due to the pigmentation effect.
Many melanomas arise suddenly. A black tiny mole suddenly appears on the skin and changes consistently over a short period of time. Obviously these "sleeping" melanomas aren't colored. However, they got colored and visible by the melanocortins, making them detectable by dermatologists.
"
This makes sense, my shoulders got a lot of moles when i started using Melanotan II which I presume we're caused by all the sunburns i got there as a kid. Melanotan II just made them visible.
Re: Melanoma associated with the use of melanotan-II.
It is something we all know, but Clinuvel confiming it, sounds more proffesional.
Good news friend !!!* ]
This article should be pinpoint to avoid other users to alarm people in forum.
"
Recently published study about Scenesse (MT1) for treatment of EPP (Erythropoietic Protoporphyria)
Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria
G. Biolcati1, E. Marchesini2, F. Sorge1, L. Barbieri1, X. Schneider-Yin3 andE.I. Minder3,*
DOI]
Free access]
http://onlinelibrary.wiley.com/doi/10.1111/bjd.13598/pdf
"Few reports on induction of either
atypical naevi or melanoma by illegal internet-distributed products containing alpha-MSH analogs
usually document a time span of a few weeks between the first dose of the illegal
product and the detection of the serious diseases30-33. The fast manifestation indicates that
the serious condition likely was present before the application of the illegal product and was
unmasked by the pigmentation enhancing effect of the alpha-MSH analog. This is consistent
with the risk profile of users of illegal products for tanning purposes, since these individuals
are more likely than the general population to expose themselves to harmful doses of intense
UV irradiation by frequent and prolonged sun exposure or the use of tanning salons34"
This is a very strong statement concerning the ability of Scenesse, or other MCR1 agonists like MT2, to detect melanomas at an early stage due to the pigmentation effect.
Many melanomas arise suddenly. A black tiny mole suddenly appears on the skin and changes consistently over a short period of time. Obviously these "sleeping" melanomas aren't colored. However, they got colored and visible by the melanocortins, making them detectable by dermatologists.
"
Re: Melanoma associated with the use of melanotan-II.
What caught my eye was "Two patients noted a
new melanocytic naevus, appearing 2.5 and 5 years after the first dose of afamelanotide, re-
spectively. One of them was removed and showed no signs of malignancy. " This was out of several hundred patients.
This means that new "moles" are not a side effect, and that it just darkens existing moles. Moles, freckles, and other terms are thrown around loosely but are actually quite different things.
The black spots people see are probably just areas of hyperpigmentation such as lentigos http://www.skinsight.com/adult/solarLentigo.htm. These are different than moles and are not as likely to turn cancerous as moles, which are already very unlikely to turn cancerous (one in thousands).
Basically these spots are probably just freckles caused by sun exposure that are indicative of sun damage more so than normal freckles. They are more darkly pigmented and take longer to fade than normal freckles after a lack of UV exposure or melanotan, or they don't fade at all.
Having a lot of moles is the #1 risk factor for melanoma, so all in all I would say it's a good thing that it is confirmed that melanotan doesn't cause new moles.
Re: Melanoma associated with the use of melanotan-II.
Very skilled debaters here !
Agrees that the MT2 reveal existing problems with the skin.
I love MT2 and has accumulated 90MG over the last six months. I take 500 mcg every day, also as maintenance. Lower doses do not work for me. I have now finally achieved the same color on the face ]
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