CJC-1295 and GHRP-6 Dose-response study

[Semin]

[b]Hexarelin-induced growth hormone, cortisol, and prolactin release]

Massoud AF, Hindmarsh PC, Brook CG.
London Center for Pediatric Endocrinology and Metabolism, Middlesex Hospital, London, United Kingdom.

Dose-response data for GH-releasing peptides are limited. We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release. In addition, we studied the effect of administration of a single dose of GHRH-(1-29)-NH2 (1.0 microgram/kg), alone or in combination with a low dose of hexarelin (0.125 microgram/kg). Dose-response curves for the maximum GH response and maximum percent change in serum PRL and cortisol concentrations from baseline were constructed. The GH dose-response curve reached a plateau of 140 mU/L, corresponding to a hexarelin dose of 1.0 microgram/kg, with an ED50 of 0.48 +/- 0.02 microgram/kg (mean +/- SEM). The PRL dose-response curve reached a plateau of 180% for the maximum percent rise from baseline, corresponding to a hexarelin dose of 1.0 microgram/kg, with an ED50 of 0.39 +/- 0.02 microgram/kg. The cortisol dose-response curve showed a step increase to approximately 40% at a hexarelin dose of 0.5 microgram/kg. The coadministration of GHRH-(1-29)-NH2 (1.0 microgram/kg) and low dose hexarelin (0.125 microgram/kg) resulted in massive GH release (115 +/- 32.8 mU/L), a moderate rise in serum PRL (84.9 +/- 27.5%), and no rise in serum cortisol. These data show that iv hexarelin was capable of inducing GH, PRL, and cortisol release in a dose-dependent manner. Low dose hexarelin was synergistic with GHRH and potent for GH release with a minimal effect on other hormones.

PMID: 8954038

[bolo]

IS THER A DOSING SCHEDULE FOR THE GHRP 6 , EX. TIME OF DAY, AND STRENGTH OF DOSE ? ALSO IF IM TAKING MTII AND CREATIN SHOULD I SPACE THEM OUT ANY ? THANKS BOLO

[Semin]

"
IS THER A DOSING SCHEDULE FOR THE GHRP 6 , EX. TIME OF DAY, AND STRENGTH OF DOSE ? ALSO IF IM TAKING MTII AND CREATIN SHOULD I SPACE THEM OUT ANY ? THANKS BOLO
"

One link on GHRP-6

5 grams creatine in the AM and 5-10 grams pre/post workout (no effect on the peptides)

100mcg GHRP-6 (give or take 50mcg) is effective for most.* Before bed is ideal time to dose and the other dosing times will work around your lifestyle and goals.* 2 or 3 ghrp injections per day is often mentioned

The tricky part of GHRP-6 and MT-2 together is that the GHRP will make you hungry (best to dose with empty stomach and not eat for 30 minutes) and the MT-2 (if taken when fasting) will curb the appetite - some find balance with these peptides...* If you were to keep the MT-2 dose around 300mcg and inject with more frequency (with the GHRP) while avoiding the anorexic feelings...things to consider

[Semin]

""

[Semin]

One option is to use the GH on the 3 workout days + the peptides. Then on non-workout days use just the peptides.

So]Workout Days

PWO Modified GRF(1-29)/GHRP wait 10 minutes and then use 2iu of the synthetic GH

Pre-bed Modified GRF(1-29)/GHRP wait 10 minutes and then use 2iu of the synthetic GH

[Semin]

Currently interested in a protocol consisting of:* 100mcg CJC-1295 w/ no DAC (modified GRF 1-29) & 100mcg Ipamorelin
Dosing post workout and pre bedtime